- Hill Family Genealogy, 1700/1999, bulk 1980/19992
- Historic Map and Government Documents Collection, 1630/19782
- James M. Guiher, Jr., Papers, 1835/2014, bulk 1927/19762
- Morley Jeffers Williams Collection, 1602/19672
- Museums at Washington and Lee records, 1649/20162
- Sheet Music Collection, 1827/19742
- Tyler Family Papers, Group D, 1939/19512
- Von Frieling's Salve collection, 1512/1977, bulk 1900/19322
- W. Jett Lauck papers, 1900/19522
- Wade Hampton Frost papers, 1880/19842
- 17th and 18th century British periodicals, 1600/18001
- A. E. Dick Howard papers, 1928/20171
- Berkeley Family Papers
1536-present1
- Bevill Family Papers, 1558/1939, bulk 1558/17071
- C. Harrison Mann, Jr. map collection, 1579/19611