- Johann Georg Weidenkeller album amicorum, 1605/16201
- John D. Hoblitzell, Jr. (1912-1962), Politician, Papers, 1956/19621
- John W. Warner papers, 1967/2009, bulk 1967/20081
- Lee Nicholson Papers, 1827/19381
- Lynch Family History, 1600/19401
- Manuscripts Artifact Collection, 1800/20101
- Margaret Forbes Brand, Compiler, Genealogies, 1500/19651
- Mining Industry, 1000/20001
- Morley Jeffers Williams Collection, 1602/19672
- Morton Genealogy Collection, 1830/19781
- Ollen Lawrence Burnette, Jr. papers, 1815/20141
- Papers of the Low Moor Iron Company
1873-19271
- Paul Stevens map collection, 1541/17782
- Performing arts manuscripts collection, 1475/19843
- Raleigh (Ralegh) and Carew family correspondence, 1500/16521