- Cambridge University Charters, 1575/16692
- Chester McNerney Collection, 1290/19502
- Sheet Music Collection, 1827/19742
- 17th and 18th century British periodicals, 1600/18001
- Bevill Family Papers, 1558/1939, bulk 1558/17071
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Collection of Spanish Language Manuscripts, 1551/18581
- Gideon Macon Family Charts, 1602/19951
- Lee Nicholson Papers, 1827/19381
- Manuscripts Artifact Collection, 1800/20101
- Morton Genealogy Collection, 1830/19781
- Richard G. Joynt Collection of British Manuscripts, 1593/20151
- Richard Lee Morton papers, 1756/2006, bulk 1930/19691
- Tyler Family Papers, Group D, 1939/19511
- Virginia Counties Collection, 1600/2000, bulk 1730/18901