- Mining Industry, 1000/20001
- Missale Romanum frisket fragment, 15821
- Morton Genealogy Collection, 1830/19781
- Ollen Lawrence Burnette, Jr. papers, 1815/20141
- Papers of the Low Moor Iron Company
1873-19271
- Paul Stevens map collection, 1541/17781
- Performing arts manuscripts collection, 1475/19842
- Raleigh (Ralegh) and Carew family correspondence, 1500/16521
- Richard J. DeMartino papers, 1910/19651
- Richard Lee Morton papers, 1756/2006, bulk 1930/19691
- Saint Andrew's Society collection, 1861/19952
- Sheet Music Collection, 1827/19742
- Shenandoah County Historical Society Collection, 1147/20001
- Tyler Family Papers, Group D, 1939/19511
- Von Frieling's Salve collection, 1512/1977, bulk 1900/19322