- Edwin W. Lynch Vietnam War protest collection, 1965/19753
- Collection of Spanish Language Manuscripts, 1551/18582
- Historical Maps Collection, 1500/20232
- James M. Guiher, Jr., Papers, 1835/2014, bulk 1927/19762
- Sheet Music Collection, 1827/19742
- Von Frieling's Salve collection, 1512/1977, bulk 1900/19322
- W. Jett Lauck papers, 1900/19522
- Wade Hampton Frost papers, 1880/19842
- A. E. Dick Howard papers, 1928/20171
- Berkeley Family Papers
1536-present1
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Chester McNerney Collection, 1290/19501
- Eileen Peters, Compiler, Genealogy, 1887/19951
- European figure engravings, 1535/18491
- George Mason University Student Government records, 1968/20191