- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19743
- Jan Karon papers, 1918/2018, bulk 1964/20182
- A. E. Dick Howard papers, 1928/20171
- Arthur J. Morris memorabilia, 1884/19921
- Carl McFarland papers, 1920/19801
- Chisholm Foundation collection on Frank Gardiner Wisner, 1909/19971
- Coleman, Bromm, Kirschmann family papers, 1861/20181
- Cultural Alliance of Greater Hampton Roads Records, 1972/20181
- Cumming Family Papers, 1818/19921
- E. Barrett Prettyman Jr. papers, 1944/1989, bulk 1953/19551
- Earle K. Shawe papers, 1938/20031
- Edward Henderson Deets Jr. memorabilia, 1943/20041
- Edward O. McCue papers, 1967/19831
- Ewing family memorabilia, 1892/19821
- Frances Farmer papers, 1900/19931