- Jack R. Levien papers, 1960/19991
- Jan Karon papers, 1918/2018, bulk 1964/20182
- Jefferson Society records, 1825/20181
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18651
- John W. Warner papers, 1967/2009, bulk 1967/20081
- Monrad G. Paulsen papers, 1960/19791
- Mortimer M. Caplin papers and memorabilia, 1930/20141
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19743
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771
- Richard B. Lillich papers, 1906/19961
- Robert H. Knight memorabilia, 1966/20101
- Roy Alson papers, 1970/1983, bulk 1970/19751
- Virginia Scott Cocke Lyman papers, 1898/2025, bulk 1899/19051
- Warren Chappell papers, 1929/20001