- Arthur J. Morris memorabilia, 1884/19921
- Beverley R. Tucker papers, 1886/19731
- Clay family memorabilia, 1892/19251
- Coleman, Bromm, Kirschmann family papers, 1861/20181
- Cumming Family Papers, 1818/19921
- Ewing family memorabilia, 1892/19821
- Frances Farmer papers, 1900/19931
- Francis H. Fife papers, 1785/2015, bulk 1940/20151
- George Washington Lewis papers, 1805/19661
- George Wilson and Elizabeth Dent Wilson family photos and memorabilia, 1870/19691
- Jefferson Society records, 1825/20181
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18651
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/197488
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771
- Virginia Scott Cocke Lyman papers, 1898/2025, bulk 1899/19051