- May family papers, 1870/19451
- Moore brothers Civil War letters and papers, 1861/18761
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/197488
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771
- Sir Fitzroy Maclean papers, 1827/19961
- Somerville family papers, 1821/20131
- Stella Pratt scrapbook, 1867/19471
- Stowe grocery store ledgers, 1870/19341
- Warren Spencer Collection, 1864/19881
- William Allen Butler family papers (and related Terry, Collins families), 1808/19591
- William W. Crapo Alabama claims cases correspondence, 1870/18761