- Charles McCamic (1874-1956) Papers, 1919/19561
- Charleston Gazette Publishing Company Records and Chilton Family Papers, 1884/20181
- Clifford Condon, Navy Pharmacist, World War II Papers, 1930/19501
- Coleman-Wilson Papers, 1775/1989, bulk 1883/19641
- Conan W. Vaughan, Jr., Papers, 1923/19921
- Daniel Monson World War II aviation collection, 1941/19581
- Daughters of the American Revolution, Elizabeth Ludington Hagans Chapter, Morgantown, West Virginia Records, 1903/19471
- Dayton and Woods Families Genealogies and Correspondence, 1849/19601
- Department of Justice papers, 1942/19511
- Donovan Bond, Journalism Professor, Personal and Professional Papers, 1861/1998, bulk 1914/19801
- Dowdy Family Letters, 1944/1969, bulk 1944/19451
- Dr. J.C. Easton, History Professor, Papers, 1860/1960, bulk 1935/19601
- E.C. and H.B. Eagle Papers, 1910/19801
- Edward E. Thompson Papers, 1932/19871
- Edward Lynch Papers, 1943/19471