- Charleston Gazette Publishing Company Records and Chilton Family Papers, 1884/20181
- Charlotte Muzichuck, Collector, Papers of Anna Santore DeLancy, 1926/19451
- Clark Family Correspondence, 1885/19391
- Clifford Condon, Navy Pharmacist, World War II Papers, 1930/19501
- Coleman-Wilson Papers, 1775/1989, bulk 1883/19641
- Conan W. Vaughan, Jr., Papers, 1923/19921
- Daughters of the American Revolution, Elizabeth Ludington Hagans Chapter, Morgantown, West Virginia Records, 1903/19471
- Dayton and Woods Families Genealogies and Correspondence, 1849/19601
- Donovan Bond, Journalism Professor, Personal and Professional Papers, 1861/1998, bulk 1914/19801
- Dr. J.C. Easton, History Professor, Papers, 1860/1960, bulk 1935/19601
- E.C. and H.B. Eagle Papers, 1910/19801
- Elizabeth Nunn Papers, 1931/19751
- Erbie Claire Albright (d. 1964) Papers, 1915/19431
- Fletcher B. Emerson letters, 1924/19501
- Francis N. Crenshaw Papers, 1927/19781