- Pauline E. Burks Family Papers, 1763/19851
- Preston Family (Alice Preston Moore Collection) Papers, 1749/18821
- Preston Family (Charles Peale Didier Collection) Papers, 1747/18971
- Preston Family Correspondence, 1861/18721
- Price Family Collection,, 1840/19051
- Rebecca Cobb Masengill Dulaney Album, 1838/18671
- Rosanna Croy Dawson Collection, 1847/19071
- Smithfield Preston Foundation Papers, 1784/18811
- Southwest Virginia Counties Collection, 1824/18851
- Sturtevant Family Letters, 1858/18841
- Sullivan Family Papers, 1800/19571
- Susana Torre Architectural Collection, 1830/2003, bulk 1967/20031
- Sutton-Martin-Mason Family Papers, 1861/19681
- The Reverend Dr. and Mrs. Richard Eugene Hager (Anne Peyton Judkins Hager) Collection, 1802/20071
- Tyler-Ellis-Marye Family Collection, 1848/19391