- Baer Family Papers, 1744/19291
- Betty Washington Lewis family papers, 1783/18441
- Bowman Family Papers, 1765/19981
- Chester McNerney Collection, 1290/19501
- Draft will of Elijah Forsythe, 1800/18201
- Historic Maps of Europe, 1572/18451
- John T. Harris papers, 1771/1937, bulk 1850/19001
- Manley Family papers, 1707/19531
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- McCown Family Papers, 1811/19171
- Monroe County (W. Va.) Court Records and Miscellaneous Papers, 1751/19271
- Patricia Turner Ritchie collection on Brocks Gap, 1750/19901
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19741
- Throckmorton Papers, 1787/18171
- Virginia Counties Collection, 1600/2000, bulk 1730/18901