- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Doris Zallen Papers, 1952/20161
- Elizabeth Fine Papers, 1983/20121
- George Grigg and John Carnochan Papers, 1969/20151
- Hard Times Blues Collection, 1966/20191
- Jack Shelton Harris and Shirley Jean Schumann Harris Papers, 1924/20141
- James I. Robertson Jr. Papers, 1849/20111
- Jean Elliott Papers, 1999/20151
- John M. and Cora Bolton McBryde Family Papers, 1862/20181
- Larry McBryde Collection on the John McLaren McBryde Family, 1859/20131
- Records of HokiePRIDE, 1971/2015, bulk 1995/20131
- Records of the Department of Philosophy and Religion and Department of Religion and Culture, 1960/20161
- Records of the Multicultural Academic Opportunities Program (MAOP), 1993/20171
- Records of the Office of the Associate Provost, Patricia Hyer, 1937/20131
- Records of the Office of the Dean of Virginia Tech Carilion School of Medicine, Cynda Ann Johnson, 2008/20181