- A.C.L. Gatewood Papers, 1801/19191
- Barns Family Records, 1884/19901
- Brooke Family Papers, 1814/1990, bulk 1880/19601
- Chappelear Collection, 1788/19591
- Charles W. Osenton (b.1865) Papers, 1847/19201
- Clarence L. Musgrave Papers, 1839/19371
- Clark Family Correspondence, 1885/19391
- Enoch Rector (1804-1898) Papers, 1824/19661
- Fort Van Metre Papers, 1780/19691
- Gravely and Moore Studio, Photography Business in Charleston, Negatives, 1860/1969, bulk 1930/19451
- Guy B. Young Papers, 1880/19401
- Harvey W. Harmer (1865-1961) Papers, 1842/19611
- Henry Ruffner (1790-1861) and William Henry (1824-1908) Papers, 1829/19131
- Holt Family Papers, 1887/19261
- Isaac McNeel (b.1830) Papers, 1850/19081