- A. Willis Robertson Papers, 1921/1988, bulk 1946/19661
- Borland Family Papers, 1771/19401
- Daingerfield Papers, 1833/19301
- Floyd-Johnston-Preston Papers, 1753/19401
- John Barton Payne Papers, 1893/1934, bulk 19201
- Mills E. Godwin, Jr. Papers, 1712/1989, bulk 1947/19891
- Tazewell Family Papers, 1838/1978, bulk 1860/18701
- Tyler Family Papers, Group A, 1716/19461
- Tyler Family Papers, Group H, 1750/19351
- William Booth Taliaferro Papers, 1811/19541
- William Munford Tuck Papers, 1918/19681