- Austin-Twyman Papers, 1765/19391
- Barraud Family Papers, 1799/1904, bulk 1810/18601
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18171
- Brown, Coalter, Tucker Papers (I), 1790/19291
- Campbell Family Papers, 1726/19201
- Christopher Tompkins Papers, 1778/18381
- Edward Coles Papers [typescripts], 1814/18571
- Francis Little Collection, 1770/18641
- Garth Family papers, 1798/18721
- James Monroe papers, 1776/1924, bulk 1783/18311
- Myers-Burrage-Graham papers (I), Group A, 1776/19251
- Preston Family Papers, 1755/1836, bulk 1786/18151
- Richard Blow Papers, 1772/18721
- Simon Snyder papers, 1819/20111
- Tyler Family Papers, Group A, 1716/19461