- Beattie Family University Memorabilia, 1875/19591
- Benjamin Cottrell Papers, 1910/19831
- Benjamin F. Cousins Papers, 1888/18891
- Bertram A. Holtzworth Scrapbook, 1918/19261
- Bertram Y. Kinzey, Jr., Papers, 1940/19551
- Billy G. Shelton Collection, 19621
- Black Women at Virginia Tech Oral History Project Records, 1967/2000, bulk 1994/20001
- C. Eugene Rowe Papers, 1949/19871
- C. Hunter Carpenter Collection, 19561
- Cadet Uniform Hardware and Insignia, 1877/19521
- Carl George Krieger Papers, 1930/19681
- Carol M. Newman, Jr., Papers, 1930/19871
- Carrie Gudheim Spear Women's Basketball Jersey, 19261
- Carrie T. Sibold Family Papers, 1912/1990, bulk 1974/19901
- Carter Perkins, Jr., Papers, 1893/19261