- Roger L. Griffith Papers, 1952/20081
- Roy Jay Holden, Jr., Papers, 1910/1989, bulk 1965/19891
- Ruth White Fisher Scrapbook, 1966/19781
- Samuel Davis Preston Papers, 1917/19721
- Sanford Bernell Fenne Papers, 1918/19701
- Sidney B. Jeffreys Papers, 1927/19851
- Stanley A. Huffman Jr. Papers, 1917/19911
- T. W. Hatcher Collection, 1919/1970, bulk 1920/19301
- University Memorabilia, 1909/20201
- VT Cheerleading Uniform Collection, 1956/20121
- VT Seal Cross Stitch, 1960/19701
- Virginia Polytechnic Institute and State University Dance Cards, 1909/20021
- Virginia Tech Alumni Association Alumni Cards, 1875/19701
- William C. Wampler Congressional Papers, 1953/1990, bulk 1967/19821
- William F. Drumeller, Jr., Collection, 1909/19911