- Austin-Twyman Papers, 1765/19391
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Brown, Coalter, Tucker Papers (I), 1790/19291
- Brown, Coalter, Tucker Papers (II), 1791/19201
- Campbell Family Papers II, 1795/19451
- Carter Braxton Collection, 1833/1922, bulk 1833/18371
- College Papers Collection, 1880/19991
- James D. Blackwell Papers, 1839/19391
- James Monroe papers, 1776/1924, bulk 1783/18311
- Jones Family Papers, 1826/19161
- Littleton Parish Register, 1840/19021
- Mongle-Hughes Papers, 1832/19161
- Nicolson Family Ledgers and Journals, 1802/19141
- Patrick H. Jones Papers, 1829/19051
- Ritchie-Harrison Papers, 1807/1938, bulk 1830/18701