- Charles A. Derby papers, 1839/18911
- Collection of Spanish Language Manuscripts, 1551/18581
- E. H. Simmons Receipts, 1847/18521
- Georgia Collection, 1806/18721
- Gibson Lamb Cranmer Papers regarding Statehood and Other Material, 1787/1895, bulk 1822/18811
- Gideon D. Camden (1805-1891) Papers, 1784/18991
- Gideon D. Camden (1805-1891) Papers, 1816/18921
- Henry Ruffner collection, 1815/18671
- John Augustine Washington III and Eleanor Love Selden correspondence, 1842/18604
- John Augustine Washington III and family papers, 1789/19941
- Lucie S. Wysong, Papers of a Jefferson County Family, 1829/1904, bulk 1871/18891
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19491
- Randolph Family papers, 1796/18821
- Rev. James M. Priest Letters, 1843/18531
- Rockbridge County records, 1778/19121