- Carlton Casey Papers, 1894/19991
- Caskie Stinnett papers, 1919/1998, bulk 1950/19931
- Charles and William Person Papers, 1900/2011, bulk 1920/19501
- Chisholm Foundation collection on Frank Gardiner Wisner, 1909/19971
- Christopher Wren Singers Records, 1989/2012, bulk 1993/20031
- Circle K International Records, 1958/2009, bulk 1958/19641
- Colonial Dames of the Commonwealth of Virginia, Susan Constant Committee, 1907/2005, bulk 1936/20051
- Colonial Piecemakers Quilt Guild scrapbook, 1988/20131
- Davis Young Paschall Collection, 1931/2001, bulk 1931/20011
- Delta Sigma Theta Sorority, Inc. Iota Alpha Chapter 50th anniversary collection, 1973/20181
- Department of Living Sciences records, 1915/20031
- Earl Gregg Swem Library records, 1920/20241
- Earl and Jewell Ratliff Collection, 1860/2013, bulk 1920/19901
- Earle K. Shawe papers, 1938/20031
- Edith McChesney Ker papers, 1948/20031