- Carlton Casey Papers, 1894/19991
- Caskie Stinnett Papers, 1919/1998, bulk 1950/19931
- Catherine Dennis Papers, 1918/1974, bulk 1918/19211
- Charles E. Kilbourne personal papers, 1898/19632
- Charles and William Person Papers, 1900/2011, bulk 1920/19501
- Chisholm Foundation collection on Frank Gardiner Wisner, 1909/19971
- Circle K International Records, 1958/2009, bulk 1958/19641
- Clarence J. Robinson papers, 1897/19781
- Coleman-Wilson Papers, 1775/1989, bulk 1883/19641
- Colonial Dames of the Commonwealth of Virginia, Susan Constant Committee, 1907/2005, bulk 1936/20051
- Daisy Bacon Papers, 1857/19861
- Davis Young Paschall Collection, 1931/2001, bulk 1931/20011
- Davis, Kline, and Hutton Family papers, 1816/19771
- Delphine Hurst Parsons papers, 1923/1976, bulk 1923/19311
- Department of Living Sciences records, 1915/20031