- Carl A. "Pappy" Fehr papers, 1907/2012, bulk 1945/19741
- Carlton Casey Papers, 1894/19991
- Carol Wolfe Scrapbook, 1954/19581
- Caskie Stinnett papers, 1919/1998, bulk 1950/19931
- Catherine Dennis Papers, 1918/1974, bulk 1918/19211
- Charles E. Kilbourne personal papers, 1898/19632
- Charles and William Person Papers, 1900/2011, bulk 1920/19501
- Chisholm Foundation collection on Frank Gardiner Wisner, 1909/19971
- Circle K International Records, 1958/2009, bulk 1958/19641
- Clarence J. Robinson papers, 1897/19781
- Coleman-Wilson Papers, 1775/1989, bulk 1883/19641
- Collection of the Hulver Family and Baughman Settlement, Hardy County, West Virginia, 1800/2013, bulk 1830/19501
- Colonial Dames of the Commonwealth of Virginia, Susan Constant Committee, 1907/2005, bulk 1936/20051
- Daisy Bacon Papers, 1857/19861
- Davis Young Paschall Collection, 1931/2001, bulk 1931/20011