- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19745
- Jean Cynthia Cheatham family papers, 1852/20122
- Alumni Association Records, 1833/2014, bulk 1950/20051
- Arthur George Williams Scrapbooks, 1905/19351
- Arthur J. Morris memorabilia, 1884/19921
- Arthur W. and Leah James Scrapbooks, 1909/19771
- Barbara Cary Johnston Willard Scrapbook, 1800/20061
- Blackley Family papers, 1830/20201
- Blacksburg Baptist Church Records, 1894/20071
- Bland Family papers, 1778/19891
- Bruce family papers, 1880/19511
- Campbell Family Papers, 1843/19501
- Carl A. "Pappy" Fehr papers, 1907/2012, bulk 1945/19741
- Carlton Casey Papers, 1894/19991
- Charles E. Kilbourne personal papers, 1898/19631