- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19744
- Alumni Association Records, 1833/2014, bulk 1950/20051
- Arthur J. Morris memorabilia, 1884/19921
- Barbara Cary Johnston Willard Scrapbook, 1800/20061
- Blackley Family papers, 1830/20201
- Blacksburg Baptist Church Records, 1894/20071
- Bland Family papers, 1778/19891
- Bruce family papers, 1880/19511
- Campbell Family Papers, 1843/19501
- Carlton Casey Papers, 1894/19991
- Charles Campbell Papers, 1743/18961
- Charles H. Bell Papers, 1772/1929, bulk 1852/18751
- Charles Page Bryan Photograph Album: "Some Beautiful Women I Have Known", 1865/19201
- Clara L. Lawrence Papers, 1763/19391
- Coleman-Wilson Papers, 1775/1989, bulk 1883/19641