- Alfred C. Payne Collection, 1917/20031
- Blacksburg Baptist Church Records, 1894/20071
- Episcopal Diocese of Southwestern Virginia Records II, 1913/19671
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/19691
- Jane Isabella Watt White papers, 1848/20171
- Nathan A. Scott Jr. papers, 1956/20011
- Norman L. Grover Papers, 1960/19921
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19741
- Robert Younger Norman Papers, 1956/19761
- Shaver and Schaeffer Family Collection, 1872/19771
- Unitarian Universalist Fellowship of the New River Valley Records, 1958/19871