- Bucktrout-Braithwaite Papers, 1780/1996, bulk 1890/18991
- Daisy Bacon Papers, 1857/19861
- Earl Gregg Swem Family Papers, 1871/19841
- Earl Gregg Swem Genealogy Collection, 1719/19821
- Eldon Bowman collection of Bowman family papers, 1797/20191
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301
- Heatwole Family Papers, 1838/20011
- Henkel Family Papers, 1801/20081
- John H. Grabill Papers, 1843/1981, bulk 1894/19221
- Sara Spotswood Royall Papers, 1900/19831
- Sixty-Seventh Field Hospital Collection, 1943/2002, bulk 1943/20021
- Skipwith Family papers, 1760/19771
- Tazewell Family Papers, 1838/1978, bulk 1860/18701
- Thelma Pedersen Collection, 1899/19881
- Travel Diaries (Europe), 1977/19891