- Lexington Arsenal and Virginia Militia records, 1702/18391
- Mary and Hannah Gibbons Papers, 1743/18901
- McGavock Family Papers, 1760/18881
- Moses Leonard Papers, 1758/17921
- Oscar Shewmake Autograph Collection, 1766/18131
- Richard Billups Papers, 1705/1857, bulk 1774/18221
- Robert Andrews Papers, 1779/1796, bulk 1781/17961
- Robert E. Lee and Lee Family papers, 1779/19261
- Skipwith Family papers, 1760/19771
- Thomas G. and Louise Rowe Pullen Collection, 1655/17911
- Tucker-Coleman papers, 1664/1945, bulk 1770/19071
- Turner Family Papers, 1778/19081
- Tyler Family Papers, Group A, 1716/19461
- United States Military Collection, 1776/19461
- Upshur Family Papers, 1662/19361