- James Noah Hess Scrapbook, 1920/19401
- John Grier Varner Papers, 1905/1978, bulk 1926/19781
- Lexington High School Commencement Program, 19341
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Marianna Broaddus Collection, 1917/19911
- Marie Katherine and Oliver E. Seegelken papers, 1918/1943, bulk 19341
- Mr. and Mrs. Donald W. Davis Collection, 1911/1994, bulk 1911/19441
- Norman E. Lau Papers, 1929/19501
- Oscar B. Barker, Jr. Collection, 1890/1974, bulk 1920/19351
- Owen G. Jarboe Scrapbooks, 1928/19481
- Person Family papers, 1872/20021
- Quisenberry Family Papers, 1900/19503
- Roane Family Papers, 1880/1973, bulk 19501
- Robert E. Lee Family papers, 1792/1935, bulk 1833/18701
- S. F. (Bill) Royall, Jr. papers, 1883/19791