- Abraham Lincoln Collection, 1860/19651
- Democratic Party Ephemera Collection, 1912/1961, bulk 1912/19281
- Ellinor Porcher Gadsden Papers, 1839/19751
- Francis P. Gaines Papers, 1803/19791
- James Noah Hess Scrapbook, 1920/19401
- John Barton Payne Collection, 1909/19321
- John Grier Varner Papers, 1905/1978, bulk 1926/19781
- Oscar B. Barker, Jr. Collection, 1890/1974, bulk 1920/19351
- Quisenberry Family Papers, 1900/19505
- Robert E. Lee Family papers, 1792/1935, bulk 1833/18701
- United Daughters of the Confederacy Collection, 1920/19391
- William E. Dold Papers, 1875/19361