- Quisenberry Family Papers, 1900/19502
- Abraham Lincoln Collection, 1860/19651
- Barton Myers Papers, 1878/19251
- Caley Family Papers, 1895/19681
- Carlton Casey Papers, 1894/19991
- Corie Lynn Dorset Rivers Collection of Ludwell-Lee-Slater Family Papers, 1805/19231
- Ellinor Porcher Gadsden Papers, 1839/19751
- Ephemera Collection, 1800/20141
- Frances Breeze Music Collection, 1890/19801
- Francis P. Gaines Papers, 1803/19791
- Geo. Gregory Smart collection of Washington and Mount Vernon ephemera, 1793/20171
- Hamilton Family Papers, 1892/2003, bulk 1930/20031
- Ivy House Restaurant Records, 1906/1985, bulk 1948/19601
- John Barton Payne Collection, 1909/19321
- John Grier Varner Papers, 1905/1978, bulk 1926/19781