- Abraham Lincoln Collection, 1860/19651
- Bagby Family Papers, 1854/19011
- Brown Family Papers, 1836/19081
- Charles H. Carson papers, 1800/19001
- Corie Lynn Dorset Rivers Collection of Ludwell-Lee-Slater Family Papers, 1805/19231
- Ellinor Porcher Gadsden Papers, 1839/19751
- Ephemera Collection, 1800/20141
- Francis P. Gaines Papers, 1803/19791
- Hugh A. Moran papers, 1865/18791
- John Turner Henley Papers, 1857/1921, bulk 1918/19211
- Lucius Desha Papers, 1868/18731
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Robert E. Lee Family papers, 1792/1935, bulk 1833/18701
- Trice Family Papers, 1830/19201
- Virginia Hot Springs Company Records, 1860/1913, bulk 1892/19031