- Camp Peary collection, 1943/19441
- Carlton Casey Papers, 1894/19991
- Charles Manson Crutchfield Collection of Memorabilia, 1882/1914, bulk 1880/18891
- Charles Page Bryan Papers, 1898/19121
- Charles R. K. Varner collection, 1881/19111
- Charles T. Smith photographs, 1880/2007, bulk 1990/19991
- Charles Triplett O'Ferrall papers, 1870/18931
- Charles Wilson Turner Collection, 19921
- Christopher Bram Papers, 1968/2014, bulk 1975/20001
- Christopher Wren Singers Records, 1989/2012, bulk 1993/20031
- Cocktail Ephemera Collection1
- Collection of Images Related to Stonewall Jackson, 1861/18751
- Collection of Photographs of Lexington, Va., 1857/19691
- Connie Smith family photograph album, 1950/19801
- Coray S. Brown family photograph collection, 1910/19601