- Blackley Family papers, 1830/20201
- Carlton Casey Papers, 1894/19991
- Charles T. Smith photographs, 1880/2007, bulk 1990/19991
- Christopher Bram Papers, 1968/2014, bulk 1975/20001
- Christopher Wren Singers Records, 1989/2012, bulk 1993/20031
- Cynthia Barlowe Collection, 1902/20011
- Earl and Jewell Ratliff Collection, 1860/2013, bulk 1920/19901
- Edith McChesney Ker papers, 1948/20031
- Ephemera Collection, 1800/20141
- Fay Parr Papers, 1920/20021
- Flippo Gallery, 1979/20231
- Heatwole Family Papers, 1838/20011
- Henkel Family Papers, 1801/20081
- Jefferson H. Clark Collection, 1914/20001
- Lavinia Scott papers, 19981