- Quisenberry Family Papers, 1900/19502
- Thomas Connors Collection, 1805/19232
- Thomas Putnam Chapman, Jr. Papers, 1875/19352
- African American Family Photographs, 1880/19601
- Bettie Hiter Willis Papers, 1864/19421
- Blackley Family papers, 1830/20201
- Carlton Casey Papers, 1894/19991
- Charles Manson Crutchfield Collection of Memorabilia, 1882/1914, bulk 1880/18891
- Charles Page Bryan Papers, 1898/19121
- Charles R. K. Varner collection, 1881/19111
- Charles T. Smith photographs, 1880/2007, bulk 1990/19991
- Collection of Photographs of Lexington, Va., 1857/19691
- Collection of the Hulver Family and Baughman Settlement, Hardy County, West Virginia, 1800/2013, bulk 1830/19501
- Crocker Family Postcards, 1900/19301
- Cynthia Barlowe Collection, 1902/20011