- Earl L. Valentine, Sr. Papers, 1940/19711
- Edith Bolling Galt Wilson Correspondence, 1951/19611
- Edward Miley Eustler scrapbook, 1910/19111
- Edwin L. Dooley, Jr. Collection, 1860/18701
- Edwin Luther Green Papers, 1865/19271
- Effinger School Collection, 1909/20116
- Ellinor Porcher Gadsden Papers, 1839/19751
- Elsie Ball Wright Bowley Papers, 1929/19721
- Emily Houston Brown Walker Scrapbook, 1934/19361
- Francis P. Gaines Papers, 1803/19791
- Francis Thomas Anderson Junkin Papers, 1910/19131
- Frank E. White Papers, 20081
- Frank J. Gilliam Papers, 1914/19641
- Franklin Lafayette Riley Papers, 1897/19271
- Frederick William McWane collection, 1909/19591