- African American Family photograph album, 1910/19601
- Anderson Family papers, 1755/19581
- Barbara Cary Johnston Willard Scrapbook, 1800/20061
- Davidson Family Papers, 1870/19751
- Earl L. Valentine, Sr. Papers, 1940/19711
- Edith Bolling Galt Wilson Correspondence, 1951/19611
- Effinger School Collection, 1909/20111
- Ellinor Porcher Gadsden Papers, 1839/19751
- Elsie Ball Wright Bowley Papers, 1929/19721
- Francis P. Gaines Papers, 1803/19791
- Frank J. Gilliam Papers, 1914/19641
- Frederick William McWane collection, 1909/19591
- Home Demonstration Clubs Papers, 1923/2010, bulk 1960/19891
- James Bernard Merrick Collection, 1927/1970, bulk 1927/19301
- James Graham Leyburn collection, 1902/19932