- Arthur M. Squires Papers, 1888/1987, bulk 1940/19871
- Blacksburg Baptist Church Records, 1894/20071
- Blake W. Corson, Jr., Papers, 1861/1984, bulk 1934/19791
- Charles S. Worley, Jr., Collection, 1950/19821
- Daniel E. Wright Papers, 1903/19731
- Duncan Alexander MacLeod Collection, 1932/19861
- Earl Palmer Appalachian Photograph and Artifact Collection, 1880/19891
- Eleanore Pettersen Architectural Collection,, 1915/2003, bulk 1950/20001
- Harry Downing Temple, Jr., Papers, 1872/2004, bulk 1930/20011
- Huddle Family Papers, 1854/19831
- Lilia Sofer Skala Student Portfolio, 1915/2003, bulk 1915/19281
- Lucy Lee Lancaster Papers, 1915/19891
- Preston Leech Glass Slides and Cassette Tape, 1900/19941
- Shaver and Schaeffer Family Collection, 1872/19771
- Sigrid L. Rupp Architectural Collection, 1950/20041