- Carter Lowance Papers, 1860/1993, bulk 1942/19881
- Catlett Family Papers, 1865/19211
- Charles E. Lipscomb Papers, 1890/19511
- Charles Edward Gary, Jr. Papers, 1870/2000, bulk 1940/19801
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/19961
- Charles H. Bell Papers, 1772/1929, bulk 1852/18751
- Charles Manson Crutchfield Collection of Memorabilia, 1882/1914, bulk 1880/18891
- Charles Mills Sheldon Papers, 1862/1928, bulk 1895/19281
- Charles Page Bryan Autograph Album, 1892/1919, bulk 1892/18971
- Charles T. Smith photographs, 1880/2007, bulk 1990/19991
- Charles and William Person Papers, 1900/2011, bulk 1920/19501
- Clara L. Lawrence Papers, 1763/19391
- Clarence J. Robinson papers, 1897/19781
- Craig Family Papers, 1860/1906, bulk 1860/18801
- Cynthia Barlowe Collection, 1902/20011