- Blackley Family papers, 1830/20201
- Bland Family papers, 1778/19891
- Charles Campbell Papers, 1743/18961
- Chester McNerney Collection, 1290/19501
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19281
- Floyd J. Whitehead Papers, 1808/18881
- History of the Case of the Commonwealth vs. Lee and Burwell Reynolds, 1800/18801
- Janet C. Kimbrough Williamsburg Area History Collection, 1873/19941
- John Frederick Pierson Papers, 1864/19251
- John Tyler, Jr. Papers, 1800/19281
- Jubal A. Early Papers, 1863/18901
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Margaret Grattan Weaver collection, 1707/1992, bulk 1857/19101
- Nathaniel Beverley Tucker Papers, 1830/1903, bulk 1850/18901
- Rev. Samuel Huntting Sayre, Jr. Papers, 1874/1989, bulk 1920/19601