- Effinger School Collection, 1909/20112
- Robert Stewart Papers, 1954/1988, bulk 1960/19802
- Abraham Anson papers, 1939/20051
- Anne and Alan Morledge Collection, 1946/2005, bulk 1969/19881
- Bonnie Atwood papers, 1965/19961
- C-SPAN records, 1809/2012, bulk 1978/20121
- Charles A. Veatch papers, 1970/20041
- Dennis Pluchinsky collection on terrorism and counterterrorism, 1956/20161
- Ephemera Collection, 1800/20141
- Fay Parr Papers, 1920/20021
- Fred Frechette Papers, 1930/2000, bulk 1950/20001
- George Mason University student publications, 1960/20241
- Guy Family Papers, 1900/19881
- J. Randolph Ruffin Papers, 1956/19931
- Jefferson H. Clark Collection, 1914/20001