- Abraham Anson papers, 1939/20051
- Anne and Alan Morledge Collection, 1946/2005, bulk 1969/19881
- Bonnie Atwood papers, 1965/19961
- Bozarth Family Papers, 1931/1985, bulk 1931/19621
- C-SPAN records, 1809/2012, bulk 1978/20121
- Charles A. Veatch papers, 1970/20041
- Dennis Pluchinsky collection on terrorism and counterterrorism, 1956/20161
- Don (Donald H.) Amador Papers, 1944/19831
- Effinger School Collection, 1909/20111
- Ephemera Collection, 1800/20141
- Fay Parr Papers, 1920/20021
- Fred Frechette Papers, 1930/2000, bulk 1950/20001
- George Mason University student publications, 1960/20241
- Guy Family Papers, 1900/19881
- J. Randolph Ruffin Papers, 1956/19931