- Career Center Records, 1939/2001, bulk 1950/19851
- Center for Student Diversity Records, 1975/20131
- Charles Center for Honors and Interdisciplinary Studies Records, 1986/20071
- Christopher Wren Association Records, 1991/20181
- Cold War Collection, 1950/19691
- College of William & Mary. Lesbian and Gay Union Records, 1980/1997, bulk 1984/19871
- Common Ground Records, 1983/20031
- Computer Center Records, 1963/20031
- Continuous Electron Beam Accelerator Facility (CEBAF), Jefferson Laboratory Records, 1982/19961
- Croushorn Family Rockingham Cooperative Farm Bureau Papers, 1932/19581