- Office of Admission records, 1861/20211
- Office of Institutional Research Records, 1975/19981
- Office of Special Programs Records, 1962/1972, bulk 1962/19721
- Office of Student Affairs Records, 1964/2013, bulk 1985/20001
- Office of the Superintendent newsletters and circulars, 1917/19561
- Omicron Delta Kappa Records, 1921/1997, bulk 1955/19711
- Omohundro Institute of Early American History and Culture Records, 1944, bulk 1950/20001
- Order of the White Jacket Records, 1972/2000, bulk 1972/20001
- Patricia Chalfant Women's Rights Collection, 1968/19781
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19748
- Presidential Scholars Program Records, 1982/19891
- Radical Roots Community Farm Collection, 2006/20081
- Rice Family Papers, 1905-1966, 1905/19661
- Robert Stewart Papers, 1954/1988, bulk 1960/19801
- Rockingham Bird Club records, 1975/20231