- Center for Student Diversity Records, 1975/20131
- Charles Center for Honors and Interdisciplinary Studies Records, 1986/20071
- Christopher Wren Association Records, 1991/20181
- Cold War Collection, 1950/19691
- College of William & Mary. Lesbian and Gay Union Records, 1980/1997, bulk 1984/19871
- Common Ground Records, 1983/20031
- Computer Center Records, 1963/20031
- Continuous Electron Beam Accelerator Facility (CEBAF), Jefferson Laboratory Records, 1982/19961
- Croushorn Family Rockingham Cooperative Farm Bureau Papers, 1932/19581
- Daniel D. Smith International School of Law collection, 1973/19781
- Department of Anthropology records, 1967/2007, bulk 1980/19951
- Department of Art and Art History Records, 1999/20221
- Department of Biology Records, 1933/2007, bulk 1960/20001
- Department of Computer Science Records, 1984/20051
- Department of English records, 1922/20131