- American Association of University Professors, College of William and Mary Chapter Records, 1924/1979, bulk 1924/19791
- Bland Family papers, 1778/19891
- Career Center Records, 1939/2001, bulk 1950/19851
- Cold War Collection, 1950/19691
- Department of Biology Records, 1933/2007, bulk 1960/20001
- Department of English records, 1922/20131
- Department of Fine Arts records, 1930/19981
- Department of Government Records, 1943/20061
- Department of History records, 1959/20231
- Department of Military Science Records, 1918/20111
- Department of Music records, 1920/20191
- Ephemera Collection, 1800/20141
- Kappa Alpha Theta, Beta Lambda Chapter Records, 1921/2005, bulk 1930/19901
- Office of Admission records, 1861/20211
- Omicron Delta Kappa Records, 1921/1997, bulk 1955/19711