- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19742
- Alumni Association Records, 1924/20161
- American Association of University Professors (AAUP). James Madison University Chapter records, 1944/19881
- American Association of University Professors, College of William and Mary Chapter Records, 1924/1979, bulk 1924/19791
- American Association of University Women (AAUW) Records, Harrisonburg, Virginia Branch, 1929/20251
- American Rhododendron Society Records, 1927/20221
- Bland Family papers, 1778/19891
- Career Center Records, 1939/2001, bulk 1950/19851
- Cold War Collection, 1950/19691
- Croushorn Family Rockingham Cooperative Farm Bureau Papers, 1932/19581
- Department of Biology Records, 1933/2007, bulk 1960/20001
- Department of English records, 1922/20131
- Department of Fine Arts records, 1930/19981
- Department of Government Records, 1943/20061
- Department of Military Science Records, 1918/20111