- Alleghany Chapter, National Society of the Daughters of the American Revolution Records,, 1890/20221
- Anna Whitehead Kenney Papers, 1965/19721
- Anne H. Price Yates Papers, 1904/1985, bulk 1975/19851
- Anne Price Yates Papers II, 1898/20051
- Association for the Preservation of Virginia Antiquities, Montgomery County Branch Papers, 1754/1996, bulk 1958/19831
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/19981
- Beulah O. Allen Collection,, 1905/1992, bulk 1920/19701
- Black Cemetery Map (Blacksburg, Virginia), 1972/19831
- Black, Kent, and Apperson Family Papers, 1779/19841
- Blacksburg Baptist Church Records, 1894/20071
- Blacksburg Chamber Music Series Collection, 1967/19821
- Campus, Virginia Polytechnic Institute and State University, 1971/19721
- Carrie T. Sibold Family Papers, 1912/1990, bulk 1974/19901
- Charles S. Worley, Jr., Collection, 1950/19821
- Charles W. Crush Collection, 1796/19781