- Charles W. Crush Collection, 1796/19781
- Charlton Family Papers, 1853/19581
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19911
- Civil War Small Manuscripts Collection, 1861/19961
- Dorothy H. Bodell Papers, 1850/19961
- Earl Palmer Appalachian Photograph and Artifact Collection, 1880/19891
- Elizabeth Kent Adams Papers, 1922/19871
- Ellett Family Papers, 1865/19611
- George Green Shackelford Papers, 1899/1990, bulk 1955/19891
- Harold C. Cox Memorabilia Collection,, 1923/19841
- Harris Mountain Schools Collection, 1913/19611
- Harry W. Sanders Papers, 1913/19811
- Henry H. Hill Collection, 1893/19631
- Huff-Hylton Families Papers, 1803/19751
- Independent Order of St. Luke Records, 1877/19701